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Question 1:
A patient requires an intravenous (IV) infusion of an active pharmaceutical ingredient (API) which obeys the one-compartment pharmacokinetic model. The therapeutic plasma concentration (Cp) for the API is 35 mg L-1, the API’s volume of distribution (V) is 18.4 L and the API’s elimination constant
(kel) is 0.165 hr-1
.
(a) Calculate a suitable infusion rate (in mg hr-1) which will achieve the therapeutic
plasma concentration when administered over 30 min.
(6 marks)
(b) Calculate the infusion rate (in mg hr-1) which will maintain the therapeutic plasma
concentration once steady state has been achieved by
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